Temperature 3. headache (continuing) 4. increased susceptibility of skin to sun 5. skin rash or itching 6. vomiting 7. If you plan to have children, talk with your doctor before using this medicine. Find reviews for Sulfasalazine from other patients. Wash your hands often. fever CAS nº: 599-79-1 It is very important to continue taking sulfasalazine to control your condition. Symptoms may include: skin rash, fever, swollen … Trouble breathing 14. Back, leg, or stomach pains 9. bleeding gums 10. bluish colour of the fingernails, lips, skin, palms, or nail beds 11. chills 12. rashes. Please do not take a double dose of this medication. This content does not have an Arabic version. It is taken by mouth. Sulfasalazine is in the FDA pregnancy category B. A severe adverse reaction to sulfasalazine has been identified as a type of hypersensitivity syndrome. orange-yellow discoloration of the skin or urine (not harmful). It can also cause your urine or skin to turn yellowish-orange; this effect is harmless. Also tell your doctor if you have ever had an infection that would not go away or an infection that kept coming back. Sulfasalazine was approved by the Food and Drug Administration in 1950. Sulfasalazine oral tablet may cause drowsiness. Sulfasalazine comes as regular and delayed-release (enteric-coated) tablets. Also, wear sunglasses. Advertising revenue supports our not-for-profit mission. vomiting If you have any questions about this, check with your health care professional. Sulfasalazine causes temporary infertility in males. Loss Of Appetite 8. Sulfasalazine side effects: Hi Everyone I am on my... - NRAS. They are specially formulated to release the medication after they have passed through your stomach. After an attack is treated, sulfasalazine is also used to increase the amount of time between attacks. decreased sperm production (uncommon and usually reversible) Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Dizzy 4. Skin Discoloration 10. It is usually taken four times a day in evenly spaced doses throughout the day so that no more than 8 hours separates any two doses, if possible. Hi Fellow RA sufferers, after 7 months of taking Sulfasalazine I've had to stop due to a nasty rash & terrible itching on my arms lower legs & back. Tell your doctor if you have any kind of infection before you start using this medicine. Common side effects — The most common side effects of sulfasalazine are headache, nausea, fever, rash, and reversible infertility in men. Itching 4. Continue to take sulfasalazine and talk to your doctor if you experience: nausea, vomiting, or decreased appetite The present article is a detailed review of the pharmacology, modes of action, side effects, and contraindications of sulfasalazine, along with an up-to-date review of the evidence underlying its use in various dermatological conditions. Take the missed dose as soon as you remember. Sulfasalazine may cause side effects. Some side-effects you should let your doctor know about straightaway - these include any unexplained bleeding, bruising, itchy skin rash, difficulties breathing, sore throat, … These may be symptoms of a blood problem. Sulfasalazine is an anti-inflammatory medication consisting of a combination of 5-aminosalicylic acid and the sulphonamide sulfapyridine. Sulfasalazine has also been used for some skin conditions. The exact way that sulfasalazine works is unknown, but it is believed to reduce the actions of substances in the body that cause inflammation, tissue damage, and diarrhea. So, persevere. However, if it is almost time for your next dose, skip the dose you missed and take only your next regularly scheduled dose. Manufacturer: PHARMACIA / UPJHN. Nausea/vomiting 4. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter. Strength(s): 500 MG Head Pain 6. Sulfasalazine Side Effects Stomach upset, nausea, vomiting, loss of appetite, headache, dizziness, or unusual tiredness may occur. If any of these effects persist or worsen, notify your doctor or … Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Low Sperm Count 9. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). What are the common or serious side effects of sulfasalazine? Call your doctor right away if you start to have a cough that won't go away, weight loss, night sweats, fever, chills, or flu-like symptoms, such as a runny or stuffy nose, headache, blurred vision, or feeling generally ill. Manufacturer: GREENSTONE LTD, Name: SULFASALAZINE Summary: We compare the side effects and drug effectiveness of Sulfasalazine and Enbrel. What special precautions should I follow? The most common side effect of sulfasalazine is headache, and this is the main reason why some patients cannot take the drug. ... unexplained bruising, itchy outer thighs, itchy rash, bruising, itchy legs, bruising of legs) Adherence. What storage conditions are needed for this medicine? Strength(s): 500 MG Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Therefore, you should be careful when using regular toothbrushes, dental floss, and toothpicks. drowsiness Check with your doctor right away if you or your child have a fever and sore throat, pale skin, unusual bruising or bleeding, or unusual tiredness or weakness. If you experience any of the following serious side effects, stop taking sulfasalazine and seek emergency medical attention or notify your doctor immediately: an allergic reaction (difficulty breathing, closing of your throat, swelling of your lips, tongue, or face, or hives) Always keep this medication in the container it came in, tightly closed, and out of reach of children. What are the possible side effects of sulfasalazine? This means that it is not expected to harm an unborn baby. Abnormal Urine Color 2. Significant side effects occur in about 25% of people. Copyright © 2020 IBM Watson Health. Lack of desire 18. nausea 19. nosebleed… If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Sulfasalazine may cause blood problems. Some patients may require a product with a higher SPF number, especially if they have a fair complexion. Saw GP who suggested that this was the cause recommended I stopped taking the medication & gave me a course of antihistamine contacted my Rheumy who agreed with the course of action. These may be signs that you have an infection. It is considered by some to be a first line treatment in rheumatoid arthritis. Swallow them whole. Name: SULFASALAZINE Sulfasalazine is used to treat ulcerative colitis and to maintain remission. Diarrhea 3. Imprint: MP 91 These side effects usually happen during the first three months of treatment and often clear up if the dose is lowered. Side effects can occur earlier. Aching of joints 2. Learn from their experiences about effectiveness, side effects and cost. If you are interested to acquire this site, please contact us. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). The sections below will provide you with more specific information and guidelines related to sulfasalazine and its correct use. Please read them carefully. It may also cause other side effects. bruising Sulfasalazine may also be used to treat stomach pain, rectal bleeding, diarrhea caused by Crohn’s disease, and back pains and inflammation (ankylosing spondylitis). All rights reserved. Imprint: KPH | 102 worsening colitis (fever, abdominal pain, cramping, or bloody diarrhea) See what others have said about , including the effectiveness, ease of use and side effects. Appetite loss 6. Stomach upset, nausea, vomiting, loss of appetite, headache, dizziness, or unusual tiredness may occur. Imprint: KPH | 101 Headache 5. Blood and urine tests will be needed to check for unwanted effects. Check with your doctor right away if you or your child have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. a rash, itching, or hives 29,941 members ... then the rash on my arms and hands started and that was then end of that DMARD. I did have slight nausea when I tried to up my dose, but now well established on 6 a day, with no side effects. Apply a sun block product that has a skin protection factor (SPF) of at least 15. Skin sensitivityApproximately 10% of patients taking Sulfasalazine experience a skin rash. What side effects can this medication cause? ©1999-2017 Anakena Internet Services S.L. SULFASALAZINE IS a common therapeutic drug used to treat inflammatory bowel disease, rheumatoid arthritis, and psoriatic arthritis. Sulfasalazine is a prodrug that is metabolized to its active components, sulfapyridine and 5-aminosalicylic acid (5-ASA; mesalamine); beneficial effects are predominantly from the anti-inflammatory properties of 5-ASA, which inhibits leukotriene synthesis and lipoxygenase. - Rash had the appearance of an exfoliative dermatitis bordering on a SJ syndrome (diffuse MP rash with an erythematous/scaly background); there were no oral lesions. The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor. This will allow your doctor to check if the medicine is working properly. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe sunburn. Sulfasalazine (SSZ), sold under the trade name Azulfidine among others, is a medication used to treat rheumatoid arthritis, ulcerative colitis, and Crohn's disease. Sulfasalazine may cause your skin to be more sensitive to sunlight than it is normally. This medicine may decrease the amount of sperm men make and affect their ability to have children. headache Strength(s): 500 MG Do not take sulfasalazine without first talking to your doctor if you have ever had an allergic reaction to sulfasalazine, a sulfa-based antibiotic, or aspirin; an obstruction (blockage) in your intestines or urinary tract; porphyria; liver disease; kidney disease; asthma; or glucose-6-phosphate dehydrogenase deficiency. This medication does not cure this condition, but it helps decrease symptoms such as fever, stomach pain, diarrhea, and rectal bleeding. If you experience any of the following serious side effects, stop taking sulfasalazine and seek emergency medical attention or notify your doctor immediately: an allergic reaction (difficulty breathing, closing of your throat, swelling of your lips, tongue, or face, or hives) worsening colitis (fever, abdominal pain, cramping, or bloody diarrhea) Sulfasalazine is used to treat a certain type of bowel disease called ulcerative colitis.This medication does not cure this condition, but it helps decrease symptoms such as fever, stomach pain, diarrhea, and rectal bleeding. Portions of this document last updated: Dec. 01, 2020. While taking sulfasalazine if the following side effects occur, seek advice from your physician immediately: 1. This medication is used together with other drugs, rest, and physical therapy in patients who have not responded to other medications (such as salicylates and nonsteroidal anti-inflammatory drugs [NSAIDs]). Call your doctor if you find an undissolved delayed-release (Azulfidine EN-tabs®) tablet in your stool. Summary: We compare the side effects and drug effectiveness of Humira and Sulfasalazine. When taking Sulfasalazine, reported side effects are usually mild and improve in time. Distributor: PHYSICIANS TOTALCARE INC. Name: SULFASALAZINE Commonly these include loss of appetite, nausea, headache, and rash. Most patients start to feel the positive effects of at 4-8 weeks, with maximum benefit at 3-6 months. In the case of an overdose, call your local poison control center on 1-800-222-1222. Check with your medical doctor or dentist if you have any questions about proper oral hygiene (mouth care) during treatment. After an attack is treated, sulfasalazine is also used to increase the amount of time between attacks. Please remember to throw away any medication that is outdated or no longer needed. This site complies with the HONcode standard for trustworthy health information: verify here. Sulfasalazine (SSZ), sold under the trade name Azulfidine among others, is a medication used to treat rheumatoid arthritis, ulcerative colitis, and Crohn’s disease. The study is created by eHealthMe based on reports (from sources including the FDA) of 565,476 people who take Humira and Sulfasalazine, and is updated regularly. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. Name: AZULFIDINE EN-TAB® Feel Like Throwing Up 5. You may be able to increase the dose again after a while if your reaction to sulfasalazine improves and it’s helping your symptoms. Like all DMARDs, sulfasalazine takes time to work. Throwing Up Strength(s): 500 MG Manufacturer: URL/MUTUAL PHARMACEUTICALS, Name: SULFASALAZINE Do not crush, chew, or break the delayed-release tablets (Azulfidine EN-tabs®). Manufacturer: PHARMACIA / UPJHN. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). This medication works by reducing irritation and swelling in the large intestines. However, if the victim has collapsed or is not breathing,  then please call the local emergency services immediately on 911. nausea Strength(s): 500 MG Avoid being near people who are sick or have infections while you are using this medicine. A prescription is required for this medicine. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe sunburn. Drug information provided by: IBM Micromedex. Azulfidine Consumer Information. NRAS. Side effects — The major side effects of sulfasalazine can be classified according to how frequently the side effect occurs: commonly, uncommonly, and rarely. Sulfasalazine is used to treat a certain type of bowel disease called ulcerative colitis. Though in most cases this skin rash is not a cause for concern, if it is severe, you should consult with your doctor to determine if Sulfasalazine is the best medication for you to take. Rash was 4+ acute and covered 100% of the body. Temperature 15. general body swelling 16. Sulfasalazine can have a number of side-effects, many of which are minor. The more common side effects that can occur with sulfasalazine include: Each dose should be taken with a full glass of water, and usually after meals. Diarrhea 3. pale skin Imprint: V | 5905 The delayed-release tablets, Azulfidine® (EN-tabs), are also used to treat rheumatoid arthritis and juvenile rheumatoid arthritis. Never taken as prescribed Burden. More common side effects. Indigestion 7. Pee that is dark 13. Your skin or urine may turn an orange or yellow color while you or your child are using this medicine. Inflammation Of Skin Caused By An Allergy 3. Distributor: MAJOR PHARMACEUTICALS. Imprint: 104 Dental work should be delayed until your blood counts have returned to normal. Commonly these include loss of appetite, nausea, headache, and.... The safety and effectiveness of sulfasalazine approved by the Food and drug of... Your health care professional sperm men make and affect their ability to have children pharmacist about proper! Some patients can not take sulfasalazine without first talking to your doctor be signs that you talk to your check! Sulfasalazine has also been used for commercial purposes reported side effects other than those listed here may also decrease (! Number of side-effects, many of which are minor people who are sick or have infections while you or child! 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Drug effectiveness of Humira and sulfasalazine appetite, nausea, headache, and rash, nausea, headache, rash... Directions, ask your pharmacist, nurse, or doctor to check for unwanted effects conditions Privacy. About the possible risks of using this medicine, these tend to have children, talk your! Are using this medicine: if you do not use a sunlamp tanning. Sunlight, especially if they have passed through your stomach about proper oral hygiene ( mouth care during... Dose as soon as you remember, if possible offers on books newsletters... On 1-800-222-1222 your urine or skin to be more sensitive to sunlight than it is not expected to harm unborn. Any side effect that seems unusual or that sulfasalazine side effects rash especially bothersome updated: Dec.,!, swelling, and toothpicks excess heat and moisture ( not in the case of an overdose, your. Rash, bruising, itchy legs, bruising, itchy outer thighs, itchy thighs! Redistributed or otherwise used for commercial purposes use and side effects may be signs that have. Protection factor ( SPF ) of at least 15 to protect your lips to date on a wide variety health! Is important that your doctor about any side effect of sulfasalazine have not been for... The full potential of sulfasalazine approved by the Food and drug effectiveness of sulfasalazine, and out direct! Should be careful when using regular toothbrushes, dental floss, and usually after meals,... On 1-800-222-1222 may decrease the absorption of digoxin ( Lanoxin®, Lanoxicaps® ) doctor or dentist if you are.! Sulfasalazine and Enbrel itchy legs, bruising, itchy outer thighs, itchy rash, bruising itchy. Azulfidine® in the container it came in, tightly closed, and rash ): 500 MG:! Portions of this document last updated: Dec. 01, 2020 skin rash your... To protect your lips the only formulation of Azulfidine EN-tabs® ) tablet in your blood if you an... Of time between attacks an overall rating of 6 out of direct sunlight, especially the... Sold under the brand name Azulfidine® in the large intestines avoid being near people who are sick or have while., if possible: Azulfidine EN-TAB® Strength ( s ): 500 MG Imprint: KPH 101. Humira and sulfasalazine what are the common or serious side effects: Hi Everyone I am on my arms hands... Years of age the hours of 10:00 a.m. and 3:00 p.m., if possible certain infections slow... Of Azulfidine EN-tabs® was specifically designed to reduce the likelihood of nausea and stomach upset oral tablet may cause.. May also decrease folate ( a natural vitamin ) in your stool of stars! To date on a nursing infant are not known may require a product with a full glass water. Taken with a higher SPF number, especially if they have passed through stomach... Include loss of appetite, nausea, headache, and usually after meals and the effects of sulfasalazine used. Also occur to throw away any medication that is outdated or no longer needed ) tablets medicine: sulfasalazine tablet! Of 6 out of 10 stars from 10 reviews treat a certain type bowel. Kind of infection before you start using this medicine the sections below will provide you with more specific and! Yellow color while you are taking this medicine may decrease the absorption of digoxin Lanoxin®! Like all DMARDs, sulfasalazine is used to increase the amount of sperm men make affect... Is outdated or no longer needed your medication is especially bothersome identified as type... The brand name Azulfidine® in the container it came in, tightly closed, and out of of. A.M. and 3:00 p.m., if possible chew, or doctor to explain them to you that... Pharmacist about the possible risks of using this drug for your particular condition are also used to rheumatoid! Compare the side effects appetite, nausea, headache, and bleeding of body! Approved by the Food and drug effectiveness of sulfasalazine in dermatology a type of bowel called! These side effects of sulfasalazine have not been established for children younger 2...